Our research focuses on developmental neurobiology and stem cell biology with an emphasis on understanding neural stem cell distribution, maintenance and function in the brain and applications of stem cell biology in treating Parkinson's disease and other neurodegenerative diseases. Other interests include changes that occur to the brain as a consequence of aging, disease or following injury. Currently, one program in the Conover laboratory involves whole brain, cellular and subcellular imaging techniques to assess the damage following repeated traumatic brain injury, the type of injury that develops following several concussive head injuries.
Figure 1: Development of the adult V-SVZ from embryonic neuroepithelium and associated corticogenesis. Repesentative ages are embryonic day (E)11.5 (Neuroepithelium); E15.5; postnatal day (P)2 (neonate); and P56 (Adult). VZ: ventricular zone; MZ: marginal zone; CP: cortical plate; V-SVZ: ventricular-subventricular zone.
Figure 2: 3D modeling & lateral ventricle (LV) volume measurements. (A) LV differences in controls and mice with scarred LV walls. (B) Representative contour tracings of LVs and total brain. (C) Volume measurements (* P<0.05). (D, E) Representative MRI based 3D LV reconstructions and longitudinal data show age-related human LV expansion.